When I was a kid, my mom bought the first Fiskars Scissors I'd ever seen.  Their orange ergonomic handles were a huge improvement in comfort from the standard-handled scissors I had been used to.  More ergonomic innovation is now available in garden pruners and loppers featuring Fiskar's PowerGear — a  gear system that dramatically increases your leverage, allowing you to snip, prune and trim with greater comfort, speed and precision.  They come in various sizes — both for the size of your pruning and the size of your hand (sizes are pretty much based on men's hand sizes, so women should order smaller).  See and buy them all at Amazon.com.